Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM423566
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
0.6±n/a nM
Citation
 Masse, CEGreenwood, JRMondal, SCowen, SDMcLean, TH TYK2 inhibitors and uses thereof US Patent  US11046698 Publication Date 6/29/2021 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM423566
Synonyms:
US10508120, Compound I-21 | US10577373, Compound I-21 | US11046698, Compound I-21
Type:
Small organic molecule
Emp. Form.:
C15H16N6O
Mol. Mass.:
296.3271
SMILES:
Cc1cc(C)cc(Nc2cc(N)n3ncc(C(N)=O)c3n2)c1
Structure:
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