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Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM423734
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
<0.2±n/a nM
Citation
 Masse, CE; Greenwood, JR; Mondal, S; Cowen, SD; McLean, TH TYK2 inhibitors and uses thereof US Patent  US11046698 Publication Date 6/29/2021 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM423734
Synonyms:
US10508120, Compound I-189 | US10577373, Compound I-189 | US11046698, Compound I-189
Type:
Small organic molecule
Emp. Form.:
C21H24FN7O3
Mol. Mass.:
441.4588
SMILES:
CNc1cc(Nc2cccnc2O[C@H]2C[C@@H](C2)OC)nc2c(cnn12)C(=O)N[C@H]1C[C@H]1F |r,wU:28.31,13.13,30.35,wD:15.18,(1.27,5.87,;2.6,5.1,;2.6,3.56,;1.27,2.79,;1.27,1.25,;-.07,.48,;-.07,-1.06,;1.27,-1.83,;1.27,-3.37,;-.07,-4.14,;-1.4,-3.37,;-1.4,-1.83,;-2.73,-1.06,;-4.07,-1.83,;-4.47,-3.32,;-5.95,-2.92,;-5.55,-1.43,;-7.29,-3.69,;-7.29,-5.23,;2.6,.48,;3.94,1.25,;5.4,.77,;6.31,2.02,;5.4,3.26,;3.94,2.79,;5.8,-.72,;7.29,-1.11,;4.71,-1.8,;5.11,-3.29,;6.2,-4.38,;4.71,-4.78,;3.62,-5.87,)|
Structure:
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