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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM508508
Substrate
n/a
Meas. Tech.
Inhibitory Test of TNAP Activity
IC50
3.80±n/a nM
Citation
 Miyazaki, S; Inui, M; Kurosaki, Y; Yamamoto, Y; Izumi, M; Soma, K; Pinkerton, A; Kishida, M Sulfonamide compounds US Patent  US11046710 Publication Date 6/29/2021 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM508508
Synonyms:
5-chloro-2-methoxy-N-[(9aR)-7-oxo-9a,10-dihydro-5H, 9H-[1,3]oxazolo[4,3-c]pyrido[3,2-f][1,4]oxazepin-3-yl]benzenesulfonamide | US11046710, Example 58
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O6S
Mol. Mass.:
425.843
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3COC(=O)N3Cc2c1 |r|
Structure:
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