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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM508510
Substrate
n/a
Meas. Tech.
Inhibitory Test of TNAP Activity
IC50
1.40±n/a nM
Citation
 Miyazaki, S; Inui, M; Kurosaki, Y; Yamamoto, Y; Izumi, M; Soma, K; Pinkerton, A; Kishida, M Sulfonamide compounds US Patent  US11046710 Publication Date 6/29/2021 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM508510
Synonyms:
5-chloro-2-methoxy-N-[(10aS)-7-oxo-7,8,9,10,10a, 11-hexahydro-5H-dipyrido[2,1-c:3′,2′-f][1,4]oxazepin-3-yl]benzenesulfonamide | US11046710, Example 59
Type:
Small organic molecule
Emp. Form.:
C19H20ClN3O5S
Mol. Mass.:
437.897
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3CCCC(=O)N3Cc2c1 |r|
Structure:
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