Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM530460
Substrate
n/a
Meas. Tech.
DHODH enzymatic assay
IC50
0.50±n/a nM
Citation
 Lindsey, D; Scott, K DIHYDROOROTATE DEHYDROGENASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM530460
Synonyms:
(S)-N-(2-Chloro-6-fluorophenyl)-5-fluoro-4-(3-(2-hydroxypropan-2-yl)-4-methyl-1H-pyrazol-1-yl)-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide | WO2022070069, Example 3
Type:
Small organic molecule
Emp. Form.:
C23H21ClF5N3O3
Mol. Mass.:
517.876
SMILES:
C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1cc(C)c(n1)C(C)(C)O)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: