Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM530461
Substrate
n/a
Meas. Tech.
DHODH enzymatic assay
IC50
0.22±n/a nM
Citation
 Lindsey, D; Scott, K DIHYDROOROTATE DEHYDROGENASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM530461
Synonyms:
N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro-4-(3-((R*)-l-hydroxyethyl)-4-methyl-1H-pyrazol-1-yl)-2-(((S)-1,1,1-trifluoropropan-2-yl)oxy)benzamide | WO2022070069, Example 4
Type:
Small organic molecule
Emp. Form.:
C20H20ClF4N5O3
Mol. Mass.:
489.851
SMILES:
C[C@@H](O)c1nn(cc1C)-c1cc(O[C@@H](C)C(F)(F)F)c(cc1F)C(=O)Nc1c(C)n[nH]c1Cl |r|
Structure:
Search PDB for entries with ligand similarity: