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Target
Beta-hexosaminidase subunit beta
Ligand
BDBM50034220
Substrate
n/a
Meas. Tech.
Inhibition of Mast Cell Degranulation
IC50
4200±n/a nM
Citation
 Schlechtingen, G; Knolker, H; Friedrichson, T; Jennings, G; Braxmeier, T Hydroxy-substituted amino and ammonium derivatives and their medical use US Patent  US10143668 Publication Date 12/4/2018 
Target
Name:
Beta-hexosaminidase subunit beta
Synonyms:
Beta-N-acetylhexosaminidase subunit beta | Beta-hexosaminidase subunit beta | Beta-hexosaminidase subunit beta (Hex B) | HEXB | HEXB_HUMAN | Hexosaminidase subunit B
Type:
Enzyme
Mol. Mass.:
63112.58
Organism:
Homo sapiens (Human)
Description:
P07686
Residue:
556
Sequence:
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLLVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNHENM
  
Inhibitor
Name:
BDBM50034220
Synonyms:
2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide | CHEMBL125 | MILTEFOSINE | [2-(Hexadecyloxy-hydroxy-phosphoryloxy)-ethyl]-trimethyl-ammonium | hexadecyl 2-(trimethyl-lambda~5~-azanyl)ethyl hydrogen phosphate | hexadecyl 2-(trimethylammonio)ethyl phosphate | hexadecyloxy-2-trimethylammonioethylphosphorate | hexadecylphosphocholine | hexadecylphosphocholine, miltefosine | n-hexadecylphosphocholine
Type:
Small organic molecule
Emp. Form.:
C21H46NO4P
Mol. Mass.:
407.568
SMILES:
CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C
Structure:
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