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Target
Serine/threonine-protein kinase B-raf [416-766,V600E]
Ligand
BDBM313482
Substrate
n/a
Meas. Tech.
In Vitro Raf Activity Determination
IC50
6391±n/a nM
Citation
 Aversa, RJ; Burger, MT; Dillon, MP; Dineen, Jr., TA; Lou, Y; Nishiguchi, GA; Ramurthy, S; Rico, AC; Rauniyar, V; Sendzik, M; Subramanian, S; Setti, LQ; Taft, BR; Tanner, HR; Wan, L Compounds and compositions as RAF kinase inhibitors US Patent  US10167279 Publication Date 1/1/2019 
Target
Name:
Serine/threonine-protein kinase B-raf [416-766,V600E]
Synonyms:
B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1
Type:
n/a
Mol. Mass.:
39690.71
Organism:
Homo sapiens (Human)
Description:
PV3849, from Invitrogen
Residue:
351
Sequence:
LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM313482
Synonyms:
3-(2-aminopropan-2-yl)- N-(3-(5-(3- hydroxyoxetan-3-yl)-6- methoxypyridin-3-yl)-4- methylphenyl)-5- (trifluoromethyl)benzamide | US10167279, Example 101
Type:
Small organic molecule
Emp. Form.:
C27H28F3N3O4
Mol. Mass.:
515.5241
SMILES:
COc1ncc(cc1C1(O)COC1)-c1cc(NC(=O)c2cc(cc(c2)C(F)(F)F)C(C)(C)N)ccc1C
Structure:
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