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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM329369
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay
IC50
3.20±n/a nM
Citation
 Swenson, RE Sphingosine 1-phosphate receptor antagonists US Patent  US9663511 Publication Date 5/30/2017 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM329369
Synonyms:
US9663511, Compound 2.
Type:
Small organic molecule
Emp. Form.:
C19H21Cl2N7O3
Mol. Mass.:
466.321
SMILES:
CC(C)c1cc(nc2n(C)nc(C)c12)N(CC(O)=O)NC(=O)Nc1cc(Cl)nc(Cl)c1
Structure:
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