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Target
Serine protease 1
Ligand
BDBM13558
Substrate
BDBM13574
Meas. Tech.
Serine Protease Inhibition Assay
Ki
16900±n/a nM
Citation
 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett 15:5344-52 (2005) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM13558
Synonyms:
2-[(4-carbamimidoylphenyl)amino]-2-(3,5-diethoxyphenyl)acetic acid | phenylglycine deriv. 6 | phenylglycine derivative 1
Type:
Small organic molecule
Emp. Form.:
C19H23N3O4
Mol. Mass.:
357.4036
SMILES:
CCOc1cc(OCC)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O
Structure:
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Substrate
Name:
BDBM13574
Synonyms:
(2S)-6-amino-2-[(2S)-2-[(2R)-2-amino-3-methylbutanamido]-4-methylpentanamido]-N-(4-nitrophenyl)hexanamide dihydrochloride | Chromogenic Substrate S-2251 | H-D-Valyl-L-leucyl-L-lysine-p-Nitroaniline dihydrochloride
Type:
Small organic molecule
Emp. Form.:
C23H38N6O5
Mol. Mass.:
478.585
SMILES:
CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
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