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Reaction Details
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TargetTrypsin
LigandBDBM13558
Substrate/CompetitorBDBM13574
Meas. Tech.Serine Protease Inhibition Assay
Ki 16900±n/a nM
Citation Zbinden, KGObst-Sander, UHilpert, KKuhne, HBanner, DWBohm, HJStahl, MAckermann, JAlig, LWeber, LWessel, HPRiederer, MATschopp, TBLave, T Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett15:5344-52 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Trypsin
Name:Trypsin I
Synonyms:Beta-Trypsin | Cationic trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:25790.52
Organism:Bos taurus (bovine)
Description:P00760
Residue:246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
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BDBM13558
NameBDBM13558
Synonyms:2-[(4-carbamimidoylphenyl)amino]-2-(3,5-diethoxyphenyl)acetic acid | phenylglycine deriv. 6 | phenylglycine derivative 1
TypeSmall organic molecule
Emp. Form.C19H23N3O4
Mol. Mass.357.4036
SMILESCCOc1cc(OCC)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O
Structure
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BDBM13574
NameBDBM13574
Synonyms:(2S)-6-amino-2-[(2S)-2-[(2R)-2-amino-3-methylbutanamido]-4-methylpentanamido]-N-(4-nitrophenyl)hexanamide dihydrochloride | Chromogenic Substrate S-2251 | H-D-Valyl-L-leucyl-L-lysine-p-Nitroaniline dihydrochloride
TypeSmall organic molecule
Emp. Form.C23H38N6O5
Mol. Mass.478.585
SMILESCC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure
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