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Target
Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM349029
Substrate
n/a
Meas. Tech.
JAK1 Inhibition Assay
IC50
550±n/a nM
Citation
 Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent  US10206907 Publication Date 2/19/2019 
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
Homo sapiens (Human)
Description:
P23458[850-1154]
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM349029
Synonyms:
N-(5-(4-(4- phenethylpiperidine-1- carbonyl(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide | US10206907, Compound 147
Type:
Small organic molecule
Emp. Form.:
C30H31N5O2
Mol. Mass.:
493.5994
SMILES:
O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCC(CCc4ccccc4)CC3)n2n1)C1CC1
Structure:
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