Reaction Details Report a problem with these data
Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM342786
Substrate
n/a
Meas. Tech.
Biochemical Screening Assay
IC50
2.00±n/a nM
Citation
 Mendez-Perez, M; Breitschopf, K; Lorenz, K; Strobel, H; Wang, L; Schiffer, A; Goerlitzer, J Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase US Patent  US9776991 Publication Date 10/3/2017 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM342786
Synonyms:
5-{4-[2-(2-Oxo-oxazolidin-3-yl)-acetyl]-piperazin-1-ylmethyl}-thiophene-2-carboxylic acid 2-trifluoromethoxy-benzylamide | US9776991, Example 156
Type:
Small organic molecule
Emp. Form.:
C23H25F3N4O5S
Mol. Mass.:
526.529
SMILES:
FC(F)(F)Oc1ccccc1CNC(=O)c1ccc(CN2CCN(CC2)C(=O)CN2CCOC2=O)s1
Structure:
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