Reaction Details Report a problem with these data
Target
Baculoviral IAP repeat-containing protein 2 [266-354]
Ligand
BDBM17344
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements.
pH
7.2±n/a
Temperature
295.15±n/a K
Ki
30±n/a nM
Citation
Zobel, K; Wang, L; Varfolomeev, E; Franklin, MC; Elliott, LO; Wallweber, HJ; Okawa, DC; Flygare, JA; Vucic, D; Fairbrother, WJ; Deshayes, K Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 1:525-33 (2006) [PubMed] Article
More Info.:
Target
Name:
Baculoviral IAP repeat-containing protein 2 [266-354]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Chimeric protein of inhibitor of apoptosis protein 2-baculovirus IAP repeat 3 (BIR3) | MIHB | RNF48 | cIAP1-BIR3 | cIAP1-BIR3/XIAP-BIR3 chimeric protein | cIAP1XBIR3
Type:
Chimeric Protein
Mol. Mass.:
10496.31
Organism:
Homo sapiens (Human)
Description:
Q13490[266-354]
Residue:
89
Sequence:
MQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPH
Inhibitor
Name:
BDBM17344
Synonyms:
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanoic acid | AVPW | L-alanyl-L-valyl-L-prolyl-L-tryptophan
Type:
Polypeptide
Emp. Form.:
C24H33N5O5
Mol. Mass.:
471.5493
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r|