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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357491
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
17.0±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357491
Synonyms:
US10214519, Example 235
Type:
Small organic molecule
Emp. Form.:
C27H25F2N5OS
Mol. Mass.:
505.582
SMILES:
CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1nc(C)cs1 |(-6.8,-.3,;-5.31,-.7,;-4.22,.39,;-2.73,-.01,;-2.18,-1.45,;-.64,-1.37,;.45,-2.45,;1.93,-2.06,;2.33,-.57,;1.24,.52,;-.24,.12,;-1.53,.96,;-1.53,2.5,;-.2,3.27,;-.2,4.81,;-1.53,5.58,;-2.87,4.81,;-4.2,5.58,;-4.2,7.12,;-5.54,4.81,;-5.54,3.27,;-4.2,2.5,;-4.2,.96,;-2.87,3.27,;3.82,-.17,;4.91,-1.26,;6.4,-.86,;6.8,.63,;5.71,1.72,;4.22,1.32,;.05,-3.94,;-1.39,-4.49,;-1.31,-6.03,;-2.4,-7.12,;.18,-6.43,;1.02,-5.14,)|
Structure:
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