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Target
Mitogen-activated protein kinase 1
Ligand
BDBM243986
Substrate
n/a
Meas. Tech.
Activated ERK2 Kinase Assay
pH
7.5±n/a
IC50
896±n/a nM
Comments
extracted
Citation
 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitors US Patent  US9546173 Publication Date 1/17/2017 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM243986
Synonyms:
US9546173, cmpd 62 | n-((s)-2-hydroxy-1-phenylethyl)-2-(((1s,4r)-4-hydroxycyclohexyl)amino)-5,5-dimethyl-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H31N5O3
Mol. Mass.:
425.5239
SMILES:
CC1(C)N(Cc2nc(N[C@@H]3CC[C@H](O)CC3)ncc12)C(=O)N[C@H](CO)c1ccccc1 |r,wU:9.8,12.12,wD:22.24,(-1.29,5.14,;-.52,3.81,;.25,5.14,;.39,2.56,;-.52,1.31,;-1.98,1.79,;-3.32,1.02,;-4.65,1.79,;-5.98,1.02,;-5.98,-.52,;-7.32,-1.29,;-7.32,-2.83,;-5.98,-3.6,;-5.98,-5.14,;-4.65,-2.83,;-4.65,-1.29,;-4.65,3.33,;-3.32,4.1,;-1.98,3.33,;1.93,2.56,;2.7,3.89,;2.7,1.23,;4.24,1.23,;5.01,2.56,;6.55,2.56,;5.01,-.11,;4.24,-1.44,;5.01,-2.77,;6.55,-2.77,;7.32,-1.44,;6.55,-.11,)|
Structure:
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