Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM19677
Substrate
BDBM19584
Meas. Tech.
Enzyme Inhibition Assay
Ki
>30000±n/a nM
Citation
 Tully, DC; Liu, H; Chatterjee, AK; Alper, PB; Williams, JA; Roberts, MJ; Mutnick, D; Woodmansee, DH; Hollenbeck, T; Gordon, P; Chang, J; Tuntland, T; Tumanut, C; Li, J; Harris, JL; Karanewsky, DS Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors. Bioorg Med Chem Lett 16:5107-11 (2006) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM19677
Synonyms:
(2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2-yl N-[2-(5-fluoro-2,3-dihydro-1H-indol-1-yl)ethyl]carbamate | Arylaminoethyl carbamate, 8
Type:
Small organic molecule
Emp. Form.:
C24H34FN3O4
Mol. Mass.:
447.5429
SMILES:
Fc1ccc2N(CCNC(=O)O[C@@H](CC3CCCCC3)C(=O)N3CCOCC3)CCc2c1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19584
Synonyms:
7-amino-3-carbamoylmethyl-4-methyl coumarin labeled fluorescent peptide | Ac-His-Lys-Phe-Lys-ACMC
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: