Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM19682
Substrate
BDBM19584
Meas. Tech.
Enzyme Inhibition Assay
Ki
6030±n/a nM
Citation
Tully, DC; Liu, H; Chatterjee, AK; Alper, PB; Williams, JA; Roberts, MJ; Mutnick, D; Woodmansee, DH; Hollenbeck, T; Gordon, P; Chang, J; Tuntland, T; Tumanut, C; Li, J; Harris, JL; Karanewsky, DS Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors. Bioorg Med Chem Lett 16:5107-11 (2006) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM19682
Synonyms:
(2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2-yl N-[(2S)-3-methyl-1-{[4-(trifluoromethoxy)phenyl]amino}butan-2-yl]carbamate | Arylaminoethyl carbamate, 13
Type:
Small organic molecule
Emp. Form.:
C26H38F3N3O5
Mol. Mass.:
529.5922
SMILES:
CC(C)[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r|