Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM19767
Substrate
BDBM19485
Meas. Tech.
Enzyme Inhibition Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
190±n/a nM
Citation
 Altmann, E; Aichholz, R; Betschart, C; Buhl, T; Green, J; Lattmann, R; Missbach, M Dipeptide nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett 16:2549-54 (2006) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM19767
Synonyms:
(2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-2-[1-(2-methyl-1H-imidazol-1-yl)acetamido]pentanamide | dipeptidyl nitrile, 16h
Type:
Small organic molecule
Emp. Form.:
C22H29N5O3
Mol. Mass.:
411.4974
SMILES:
CC(C)C[C@H](NC(=O)Cn1ccnc1C)C(=O)N[C@@H](COCc1ccccc1)C#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19485
Synonyms:
Cbz-Phe-Arg-AMC | Fluorogenic substrate | Z-Phe-Arg-AMC.HCl
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: