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Target
D(1A) dopamine receptor
Ligand
BDBM371854
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay for DDR1
IC50
7988±n/a nM
Citation
 Buettelmann, B; Kocer, B; Kuhn, B; Prunotto, M; Richter, H; Ritter, M; Rudolph, M; Satz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent  US10239876 Publication Date 3/26/2019 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM371854
Synonyms:
2-(4-Oxo-1-phenyl-8-(tetrazolo[1,5-a]pyridine-6-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2,2,2-trifluoroethyl)acetamide | US10239876, Example 18 | US10435407, Example 18
Type:
Small organic molecule
Emp. Form.:
C23H23F3N8O3
Mol. Mass.:
516.4757
SMILES:
FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3nnnn3c2)C1=O
Structure:
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