Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM22496
Substrate
BDBM10852
Meas. Tech.
96-Well Adherent Reporter Cell Assay
Temperature
295.15±n/a K
EC50
79±47 nM
Comments
69 +/- 10 % of the maximal response relative to the activity produced by linoleic acid.
Citation
 McKeown, SC; Corbett, DF; Goetz, AS; Littleton, TR; Bigham, E; Briscoe, CP; Peat, AJ; Watson, SP; Hickey, DM Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor. Bioorg Med Chem Lett 17:1584-9 (2007) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM22496
Synonyms:
3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid | CHEMBL207881 | carboxylic acid agonist, 2
Type:
Small organic molecule
Emp. Form.:
C22H21NO3
Mol. Mass.:
347.407
SMILES:
OC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1
Structure:
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Substrate