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TargetSphingosine 1-phosphate receptor 5
LigandBDBM23165
Substrate/CompetitorBDBM22202
Meas. Tech.[32P] S1P Binding Assay
pH7.5±n/a
Temperature277.15±n/a K
Ki 2.2±0.25 nM
Citation Kiuchi, MAdachi, KTomatsu, AChino, MTakeda, STanaka, YMaeda, YSato, NMitsutomi, NSugahara, KChiba, K Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Bioorg Med Chem13:425-32 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Sphingosine 1-phosphate receptor 5
Name:Sphingosine 1-phosphate receptor 5
Synonyms:Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41796.42
Organism:Homo sapiens (Human)
Description:n/a
Residue:398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
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BDBM23165
NameBDBM23165
Synonyms:CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy]phosphonic acid
TypeSmall organic molecule
Emp. Form.C19H34NO5P
Mol. Mass.387.4507
SMILESCCCCCCCCc1ccc(CC[C@](N)(CO)COP(O)(O)=O)cc1 |r|
Structure
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BDBM22202
NameBDBM22202
Synonyms:S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphate | sphingosine-1-phosphate, 32P labeled | sphingosine-1-phosphate, 33P labeled | {[(4Z)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid
Typeradiolabeled ligand
Emp. Form.C18H38NO5P
Mol. Mass.379.4718
SMILESCCCCCCCCCCCCC\C=C/C(O)C(N)COP(O)(O)=O
Structure
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