Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM262004
Substrate
n/a
Meas. Tech.
FGFR Enzymatic Assay 1
IC50
115±n/a nM
Citation
 Lu, L; Shen, B; Sokolsky, A; Wang, X; Wu, L; Yao, W; Ye, Y Bicyclic heterocycles as FGFR4 inhibitors US Patent  US9708318 Publication Date 7/18/2017 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM262004
Synonyms:
3-(2,6-difluoro-3,5- dimethoxyphenyl)-1-(3,5- difluorophenyl)-7-(1,3-dimethyl- 1H-pyrazol-4-yl)-3,4- dihydropyrido[4,3-d]pyrimidin- 2(1H)-one | US10251892, Example 103 | US10632126, Example 103 | US11173162, Example 103 | US9708318, 103
Type:
Small organic molecule
Emp. Form.:
C26H21F4N5O3
Mol. Mass.:
527.4703
SMILES:
COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cc(F)cc(F)c2)-c2cn(C)nc2C)c1F
Structure:
Search PDB for entries with ligand similarity: