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Target
cAMP-dependent protein kinase catalytic subunit alpha
Ligand
BDBM27238
Substrate
BDBM27221
Meas. Tech.
Fluorescence Polarization-Based Binding Displacement Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
Kd
13500±600 nM
Citation
 Lavogina, D; Lust, M; Viil, I; König, N; Raidaru, G; Rogozina, J; Enkvist, E; Uri, A; Bossemeyer, D Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases. J Med Chem 52:308-21 (2009) [PubMed]  Article 
Target
Name:
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:
KAPCA_MOUSE | PKA C-alpha | Pkaca | Prkaca | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:
Enzyme Catalytic Unit
Mol. Mass.:
40579.18
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
  
Inhibitor
Name:
BDBM27238
Synonyms:
6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-benzylhexanamide | ARC-1009, 12
Type:
Small organic molecule
Emp. Form.:
C23H29N7O5
Mol. Mass.:
483.5203
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)NCCCCCC(=O)NCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM27221
Synonyms:
Adc-Ahx-(D-Arg)(6)-D-Lys(5-TAMRA)-NH2 | Fluorescent probe ARC-583
Type:
5-TAMRA labeled compound
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: