Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha [200-419]
Ligand
BDBM36810
Substrate
n/a
Meas. Tech.
Competitive Assay
pH
8±0
Temperature
277.15±0 K
Ki
2.0±0.0 nM
Citation
 Géhin, M; Vivat, V; Wurtz, JM; Losson, R; Chambon, P; Moras, D; Gronemeyer, H Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol 6:519-29 (1999) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha [200-419]
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic Acid Receptor, alpha
Type:
Ligand-binding domain
Mol. Mass.:
24746.59
Organism:
Homo sapiens (Human)
Description:
P10276[200-419]
Residue:
220
Sequence:
PALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
  
Inhibitor
Name:
BDBM36810
Synonyms:
BMS753 | US9963439, BMS753
Type:
Small organic molecule
Emp. Form.:
C21H21NO4
Mol. Mass.:
351.3957
SMILES:
CC1(C)C(=O)C(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
Structure:
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