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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34977
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
5361.1±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34977
Synonyms:
(4Z)-4-[(2-hydroxyethylamino)methylene]-5-keto-2-methyl-benzo[g]benzofuran-3-carboxylic acid ethyl ester | (4Z)-4-[(2-hydroxyethylamino)methylidene]-2-methyl-5-oxo-3-benzo[g]benzofurancarboxylic acid ethyl ester | MLS000761560 | SMR000371659 | cid_5546403 | ethyl (4Z)-4-[(2-hydroxyethylamino)methylidene]-2-methyl-5-oxidanylidene-benzo[g][1]benzofuran-3-carboxylate | ethyl (4Z)-4-[(2-hydroxyethylamino)methylidene]-2-methyl-5-oxobenzo[g][1]benzofuran-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H19NO5
Mol. Mass.:
341.3579
SMILES:
CCOC(=O)c1c(C)oc2c1c(C=NCCO)c(O)c1ccccc21 |w:13.14|
Structure:
Search PDB for entries with ligand similarity: