Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM55023
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3).
IC50
23156±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). PubChem Bioassay (2009)[AID] 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM55023
Synonyms:
2-(4-chlorophenyl)-5-(2-furanyl)-N-propan-2-yl-3-pyrazolecarboxamide | 2-(4-chlorophenyl)-5-(2-furyl)-N-isopropyl-pyrazole-3-carboxamide | 2-(4-chlorophenyl)-5-(furan-2-yl)-N-propan-2-yl-pyrazole-3-carboxamide | 2-(4-chlorophenyl)-5-(furan-2-yl)-N-propan-2-ylpyrazole-3-carboxamide | MLS000564152 | SMR000151720 | cid_2382321
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O2
Mol. Mass.:
329.781
SMILES:
CC(C)NC(=O)c1cc(nn1-c1ccc(Cl)cc1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: