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Target
Heat shock factor protein 1
Ligand
BDBM63360
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63360
Synonyms:
2-[[(E)-3-(2,4-dichlorophenyl)-1-oxoprop-2-enyl]amino]-N,N,4-trimethyl-5-thiazolecarboxamide | 2-[[(E)-3-(2,4-dichlorophenyl)acryloyl]amino]-N,N,4-trimethyl-thiazole-5-carboxamide | 2-[[(E)-3-(2,4-dichlorophenyl)prop-2-enoyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide | 2-{[3-(2,4-dichlorophenyl)acryloyl]amino}-N,N,4-trimethyl-1,3-thiazole-5-carboxamide | MLS000672957 | SMR000272177 | cid_1290276
Type:
Small organic molecule
Emp. Form.:
C16H15Cl2N3O2S
Mol. Mass.:
384.28
SMILES:
CN(C)C(=O)c1sc(NC(=O)\C=C\c2ccc(Cl)cc2Cl)nc1C
Structure:
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