Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54384
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
2603±180.5 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54384
Synonyms:
MLS000757219 | N-(4-bromanylnaphthalen-1-yl)-1-oxidanyl-naphthalene-2-carboxamide | N-(4-bromo-1-naphthalenyl)-1-hydroxy-2-naphthalenecarboxamide | N-(4-bromo-1-naphthyl)-1-hydroxy-2-naphthamide | N-(4-bromonaphthalen-1-yl)-1-hydroxynaphthalene-2-carboxamide | SMR000529047 | cid_353380
Type:
Small organic molecule
Emp. Form.:
C21H14BrNO2
Mol. Mass.:
392.245
SMILES:
Oc1c(ccc2ccccc12)C(=O)Nc1ccc(Br)c2ccccc12
Structure:
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