Reaction Details Report a problem with these data
Target
Bcl-2-like protein 11
Ligand
BDBM66588
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis
EC50
>350000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis PubChem Bioassay (2010)[AID] 
Target
Name:
Bcl-2-like protein 11
Synonyms:
B2L11_HUMAN | BCL2-like 11 isoform 1 | BCL2L11 | BIM
Type:
PROTEIN
Mol. Mass.:
22175.26
Organism:
Homo sapiens (Human)
Description:
EBI_101325
Residue:
198
Sequence:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
  
Inhibitor
Name:
BDBM66588
Synonyms:
7-(4-chlorobenzyl)-5,8-diketo-1,3,6,8a-tetrahydrothiazolo[3,4-a]pyrazine-3-carboxylic acid methyl ester | 7-[(4-chlorophenyl)methyl]-5,8-dioxo-1,3,6,8a-tetrahydrothiazolo[3,4-a]pyrazine-3-carboxylic acid methyl ester | MLS000720858 | SMR000334213 | cid_4663601 | methyl 7-(4-chlorobenzyl)-5,8-dioxohexahydro[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate | methyl 7-[(4-chlorophenyl)methyl]-5,8-bis(oxidanylidene)-1,3,6,8a-tetrahydro-[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate | methyl 7-[(4-chlorophenyl)methyl]-5,8-dioxo-1,3,6,8a-tetrahydro-[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H15ClN2O4S
Mol. Mass.:
354.809
SMILES:
COC(=O)C1SCC2N1C(=O)CN(Cc1ccc(Cl)cc1)C2=O
Structure:
Search PDB for entries with ligand similarity: