Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72718
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
42860±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72718
Synonyms:
1-Methyl-1H-indole-3-carboxylic acid [1-(4-bromo-thiophen-2-yl)-meth-(E)-ylidene]-hydrazide | MLS000333260 | N-[(4-bromanylthiophen-2-yl)methylideneamino]-1-methyl-indole-3-carboxamide | N-[(4-bromo-2-thienyl)methyleneamino]-1-methyl-indole-3-carboxamide | N-[(4-bromo-2-thiophenyl)methylideneamino]-1-methyl-3-indolecarboxamide | N-[(4-bromothiophen-2-yl)methylideneamino]-1-methylindole-3-carboxamide | SMR000436549 | cid_2048117
Type:
Small organic molecule
Emp. Form.:
C15H12BrN3OS
Mol. Mass.:
362.244
SMILES:
Cn1cc(C(=O)NN=Cc2cc(Br)cs2)c2ccccc12
Structure:
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