Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM67275
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
35254±6375 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM67275
Synonyms:
(5E)-5-[(3,4-dimethylphenyl)hydrazinylidene]-8-quinolinone | (5E)-5-[(3,4-dimethylphenyl)hydrazinylidene]quinolin-8-one | (5E)-5-[(3,4-dimethylphenyl)hydrazono]quinolin-8-one | 5-[(E)-(3,4-dimethylphenyl)diazenyl]quinolin-8-ol | MLS000681762 | SMR000312805 | cid_16194446
Type:
Small organic molecule
Emp. Form.:
C17H15N3O
Mol. Mass.:
277.3205
SMILES:
Cc1ccc(cc1C)N=Nc1ccc(O)c2ncccc12 |w:8.8|
Structure:
Search PDB for entries with ligand similarity: