Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM76263
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
4780±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM76263
Synonyms:
1-methyl-2-oxidanyl-4-oxidanylidene-N-pyrimidin-2-yl-quinoline-3-carboxamide | 2-hydroxy-1-methyl-4-oxo-N-(2-pyrimidinyl)-3-quinolinecarboxamide | 2-hydroxy-1-methyl-4-oxo-N-pyrimidin-2-ylquinoline-3-carboxamide | 2-hydroxy-4-keto-1-methyl-N-(2-pyrimidyl)quinoline-3-carboxamide | MLS000104618 | SMR000054551 | cid_608628
Type:
Small organic molecule
Emp. Form.:
C15H12N4O3
Mol. Mass.:
296.2808
SMILES:
Cn1c2ccccc2c(O)c(C(=O)Nc2ncccn2)c1=O
Structure:
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