Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80476
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
2690±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80476
Synonyms:
MLS000856438 | SMR000279383 | [4-(1-methylpiperidin-1-ium-1-yl)-8-bicyclo[3.2.1]octanyl] acetate;iodide | [4-(1-methylpiperidin-1-ium-1-yl)-8-bicyclo[3.2.1]octanyl] ethanoate;iodide | acetic acid [4-(1-methyl-1-piperidin-1-iumyl)-8-bicyclo[3.2.1]octanyl] ester;iodide | acetic acid [4-(1-methylpiperidin-1-ium-1-yl)-8-bicyclo[3.2.1]octanyl] ester;iodide | cid_16192577
Type:
Small organic molecule
Emp. Form.:
C16H28NO2
Mol. Mass.:
266.3985
SMILES:
[H]C12CCC([H])(C1OC(C)=O)C(CC2)[N+]1(C)CCCCC1 |TLB:14:11:6:3.2|
Structure:
