Reaction Details
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GABA(A) receptor-associated protein
Ligand
BDBM50060321
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_20
Citation
Evans, BE; Bock, MG; Rittle, KE; DiPardo, RM; Whitter, WL; Veber, DF; Anderson, PS; Freidinger, RM Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. Proc Natl Acad Sci U S A 83:4918-22 (1986) [PubMed] Article More Info.:
Target
Name:
GABA(A) receptor-associated protein
Synonyms:
GABA A Benzodiazepine | GABA-A receptor subunit alpha 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13921.89
Organism:
GUINEA PIG
Description:
D7RA28
Residue:
117
Sequence:
MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL
Inhibitor
Name:
BDBM50060321
Synonyms:
1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | 1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | CCK antagonist synthetic 19 | CHEMBL419764
Type:
Small organic molecule
Emp. Form.:
C25H20N4O2
Mol. Mass.:
408.4519
SMILES:
CN1c2ccccc2C(=N[C@@H](NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1 |c:9|
Structure:
