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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50006987
Substrate
n/a
Meas. Tech.
ChEMBL_201262 (CHEMBL804880)
IC50
8±n/a nM
Citation
 Wilson, AA; Dannals, RF; Ravert, HT; Sonders, MS; Weber, E; Wagner, HN Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines. J Med Chem 34:1867-70 (1991) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50006987
Synonyms:
CHEMBL55769 | N-Adamantan-1-yl-N'-(3-iodo-phenyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C17H22IN3
Mol. Mass.:
395.2811
SMILES:
NC(Nc1cccc(I)c1)=NC12CC3CC(CC(C3)C1)C2 |w:10.11,TLB:14:15:19:13.12.18,THB:14:13:19:15.20.16,16:15:12:17.19.18,16:17:12:15.20.14|
Structure:
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