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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50008068
Substrate
n/a
Meas. Tech.
ChEBML_138791
IC50
2100±n/a nM
Citation
 Shapiro, G; Floersheim, P; Boelsterli, J; Amstutz, R; Bolliger, G; Gammenthaler, H; Gmelin, G; Supavilai, P; Walkinshaw, M Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor. J Med Chem 35:15-27 (1992) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50008068
Synonyms:
CHEMBL327819 | Dimethyl-(2-methyl-[1,3]dioxolan-4-ylmethyl)-amine | Methamilane
Type:
Small organic molecule
Emp. Form.:
C7H15NO2
Mol. Mass.:
145.1995
SMILES:
CC1OCC(CN(C)C)O1
Structure:
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