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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50007522
Substrate/Competitorn/a
Meas. Tech.ChEBML_61757
IC50 1.2±n/a nM
Citation Högberg, Tde Paulis, TJohansson, LKumar, YHall, HOgren, SO Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study. J Med Chem33:2305-9 (1990) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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  Blast E-value cutoff:
BDBM50007522
NameBDBM50007522
Synonyms:5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dimethoxy-benzamide | 5-bromo-N-((1-ethylpyrrolidin-2-yl)methyl)-2,3-dimethoxybenzamide | CHEMBL289330
TypeSmall organic molecule
Emp. Form.C16H23BrN2O3
Mol. Mass.371.269
SMILESCCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC |r|
Structure
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