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Reaction Details
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TargetPlatelet activating factor receptor
LigandBDBM50011852
Substrate/Competitorn/a
Meas. Tech.ChEBML_154999
IC50 20±n/a nM
Citation Walser, AFlynn, TMason, CCrowley, HMaresca, CO'Donnell, M Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2. J Med Chem34:1440-6 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Platelet activating factor receptor
Name:Platelet activating factor receptor
Synonyms:PAF Platelet activating factor | PAF-R | Platelet-activating factor receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:39219.60
Organism:Homo sapiens (Human)
Description:PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50011852
NameBDBM50011852
Synonyms:4-(2-Chloro-phenyl)-2-(2-indan-5-yl-ethyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene | CHEMBL289463
TypeSmall organic molecule
Emp. Form.C26H23ClN4S
Mol. Mass.459.006
SMILESCc1nnc2CN=C(c3cc(CCc4ccc5CCCc5c4)sc3-n12)c1ccccc1Cl |c:6|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a