Reaction Details Report a problem with these data
Target
Cystathionine gamma-lyase
Ligand
BDBM39346
Substrate
n/a
Meas. Tech.
ChEMBL_1721611 (CHEMBL4136611)
IC50
270000±n/a nM
Citation
 Bhattacharjee, A; Sinha, A; Ratia, K; Yin, L; Delgado-Rivera, L; Petukhov, PA; Thatcher, GRJ; Wardrop, DJ 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine ?-Lyase (CSE). ACS Med Chem Lett 8:1241-1245 (2017) [PubMed]  Article 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM39346
Synonyms:
(2S)-2-amino-3-mercapto-3-methyl-butyric acid;hydrochloride | (2S)-2-amino-3-mercapto-3-methylbutanoic acid;hydrochloride | (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;hydrochloride | (2S)-2-azanyl-3-methyl-3-sulfanyl-butanoic acid;hydrochloride | Cuprenil | D(-)PENICILLAMINE HYDROCHLORIDE | Depen | MLS000028669 | Penicillamine | SMR000058903 | cid_92173
Type:
Small organic molecule
Emp. Form.:
C5H11NO2S
Mol. Mass.:
149.211
SMILES:
CC(C)(S)[C@@H](N)C(O)=O
Structure:
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