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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50016609
Substrate
n/a
Meas. Tech.
ChEMBL_31945 (CHEMBL640407)
IC50
670.0±n/a nM
Citation
 DeRuiter, J; Swearingen, BE; Wandrekar, V; Mayfield, CA Synthesis and in vitro aldose reductase inhibitory activity of compounds containing an N-acylglycine moiety. J Med Chem 32:1033-8 (1989) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50016609
Synonyms:
(2-Oxo-2H-benzo[cd]indol-1-yl)-acetic acid | CHEMBL8381
Type:
Small organic molecule
Emp. Form.:
C13H9NO3
Mol. Mass.:
227.2155
SMILES:
OC(=O)CN1C(=O)c2cccc3cccc1c23
Structure:
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