Reaction Details Report a problem with these data
Target
Dihydropteridine reductase
Ligand
BDBM50025878
Substrate
n/a
Meas. Tech.
ChEMBL_50920 (CHEMBL664148)
Ki
3300±n/a nM
Citation
 Gessner, W; Brossi, A; Shen, R; Abell, CW Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Med Chem 28:311-7 (1985) [PubMed]  Article 
Target
Name:
Dihydropteridine reductase
Synonyms:
DHPR_RAT | Dhpr | Qdpr
Type:
PROTEIN
Mol. Mass.:
25554.95
Organism:
Rattus norvegicus
Description:
ChEMBL_54067
Residue:
241
Sequence:
MAASGEARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASASVIVKMTDSFTEQADQVTAEVGKLLGDQKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPSGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGNKRPNSGSLIQVVTTDGKTELTPAYF
  
Inhibitor
Name:
BDBM50025878
Synonyms:
4-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-benzene-1,2-diol | CHEMBL323998
Type:
Small organic molecule
Emp. Form.:
C12H15NO2
Mol. Mass.:
205.253
SMILES:
CN1CCC(=CC1)c1ccc(O)c(O)c1 |c:4|
Structure:
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