Target
Adenosine receptor A1
Ligand
BDBM50040371
Substrate
n/a
Meas. Tech.
ChEMBL_28668 (CHEMBL649066)
IC50
610±n/a nM
Citation
 Buckle, DRArch, JRConnolly, BJFenwick, AEFoster, KAMurray, KJReadshaw, SASmallridge, MSmith, DG Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. J Med Chem 37:476-85 (1994) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50040371
Synonyms:
1,3-Bis-cyclopropylmethyl-7-(4-methoxy-benzyl)-8-[1-methyl-pyrrolidin-(2Z)-ylideneamino]-3,7-dihydro-purine-2,6-dione | CHEMBL144196
Type:
Small organic molecule
Emp. Form.:
C26H32N6O3
Mol. Mass.:
476.5707
SMILES:
COc1ccc(Cn2c(N=C3CCCN3C)nc3n(CC4CC4)c(=O)n(CC4CC4)c(=O)c23)cc1 |w:9.8|
Structure:
Search PDB for entries with ligand similarity: