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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50046063
Substrate
n/a
Meas. Tech.
ChEBML_154444
IC50
42000±n/a nM
Citation
 Smyth, MS; Stefanova, I; Horak, ID; Burke, TR Hydroxylated 2-(5'-salicyl)naphthalenes as protein-tyrosine kinase inhibitors. J Med Chem 36:3015-20 (1993) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50046063
Synonyms:
5-(5,6-Dihydroxy-naphthalen-2-yl)-2-hydroxy-benzoic acid | CHEMBL103960
Type:
Small organic molecule
Emp. Form.:
C17H12O5
Mol. Mass.:
296.2742
SMILES:
OC(=O)c1cc(ccc1O)-c1ccc2c(O)c(O)ccc2c1
Structure:
Search PDB for entries with ligand similarity: