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Target
Transporter
Ligand
BDBM50051756
Substrate
n/a
Meas. Tech.
ChEMBL_142970 (CHEMBL751450)
Ki
5100±n/a nM
Citation
 Davies, HM; Kuhn, LA; Thornley, C; Matasi, JJ; Sexton, T; Childers, SR Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site. J Med Chem 39:2554-8 (1996) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50051756
Synonyms:
1-{3-[4-(1-Ethyl-propyl)-phenyl]-8-aza-bicyclo[3.2.1]oct-2-yl}-propan-1-one | CHEMBL87678
Type:
Small organic molecule
Emp. Form.:
C21H31NO
Mol. Mass.:
313.4769
SMILES:
CCC(CC)c1ccc(cc1)C1CC2CCC(N2)C1C(=O)CC |THB:19:18:17:15.14|
Structure:
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