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Target
Beta-lactamase
Ligand
BDBM50067050
Substrate
n/a
Meas. Tech.
ChEMBL_41025 (CHEMBL655042)
KOFF
0.001200 s-1
KON
1.5 M-1s-1
Citation
 Heinze-Krauss, I; Angehrn, P; Charnas, RL; Gubernator, K; Gutknecht, EM; Hubschwerlen, C; Kania, M; Oefner, C; Page, MG; Sogabe, S; Specklin, JL; Winkler, F Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams. J Med Chem 41:3961-71 (1998) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_PSEAE | ampC | beta-Lactamase
Type:
Enzyme
Mol. Mass.:
43406.87
Organism:
Pseudomonas aeruginosa (PAO1)
Description:
P24735
Residue:
397
Sequence:
MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
  
Inhibitor
Name:
BDBM50067050
Synonyms:
CHEMBL336630 | Sodium; (1S,5R)-7-oxo-2-(piperidin-4-ylcarbamoyl)-2,6-diaza-bicyclo[3.2.0]heptane-6-sulfonate
Type:
Small organic molecule
Emp. Form.:
C11H17N4O5S
Mol. Mass.:
317.342
SMILES:
[O-]S(=O)(=O)N1[C@@H]2CCN([C@@H]2C1=O)C(=O)NC1CCNCC1
Structure:
Search PDB for entries with ligand similarity: