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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50067746
Substrate
n/a
Meas. Tech.
ChEMBL_28169 (CHEMBL644123)
IC50
12±n/a nM
Citation
 Tanaka, A; Terasawa, T; Hagihara, H; Ishibe, N; Sawada, M; Sakuma, Y; Hashimoto, M; Takasugi, H; Tanaka, H Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem 41:4408-20 (1998) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50067746
Synonyms:
3-(4-Chloro-6-methyl-2-methylsulfanyl-pyridin-3-yl)-1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-urea | CHEMBL344868
Type:
Small organic molecule
Emp. Form.:
C28H31ClFN3O2S
Mol. Mass.:
528.081
SMILES:
CSc1nc(C)cc(Cl)c1NC(=O)N(Cc1ccc(Oc2ccc(F)cc2)cc1)C1CCCCCC1
Structure:
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