Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50069194
Substrate
n/a
Meas. Tech.
ChEBML_212736
Ki
3000±n/a nM
Citation
 Sanderson, PE; Cutrona, KJ; Dorsey, BD; Dyer, DL; McDonough, CM; Naylor-Olsen, AM; Chen, IW; Chen, Z; Cook, JJ; Gardell, SJ; Krueger, JA; Lewis, SD; Lin, JH; Lucas, BJ; Lyle, EA; Lynch, JJ; Stranieri, MT; Vastag, K; Shafer, JA; Vacca, JP L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor. Bioorg Med Chem Lett 8:817-22 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50069194
Synonyms:
CHEMBL355441 | N-(6-Amino-pyridin-3-ylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C21H23N5O4S
Mol. Mass.:
441.503
SMILES:
Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)NCc1ccc(N)nc1
Structure:
Search PDB for entries with ligand similarity: