Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor A
Ligand
BDBM50514582
Substrate
n/a
Meas. Tech.
ChEMBL_1857654 (CHEMBL4358383)
IC50
2900000±n/a nM
Citation
 Juillerat-Jeanneret, L The Other Angiotensin II Receptor: AT J Med Chem 63:1978-1995 (2020) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor A
Synonyms:
AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40910.53
Organism:
RAT
Description:
ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:
359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
  
Inhibitor
Name:
BDBM50514582
Synonyms:
CHEMBL155836
Type:
Small organic molecule
Emp. Form.:
C32H29NO5
Mol. Mass.:
507.5764
SMILES:
COc1ccc2CN(C(Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: