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Target
B-cell lymphoma 6 protein
Ligand
BDBM50520219
Substrate
n/a
Meas. Tech.
ChEMBL_1879422 (CHEMBL4380816)
IC50
860±n/a nM
Citation
 Guo, W; Xing, Y; Zhang, Q; Xie, J; Huang, D; Gu, H; He, P; Zhou, M; Xu, S; Pang, X; Liu, M; Yi, Z; Chen, Y Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of  J Med Chem 63:676-695 (2020) [PubMed]  Article 
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
  
Inhibitor
Name:
BDBM50520219
Synonyms:
CHEMBL4530646
Type:
Small organic molecule
Emp. Form.:
C14H16ClFN4O2
Mol. Mass.:
326.754
SMILES:
COc1ccc(Nc2nc(NCCCO)ncc2F)cc1Cl
Structure:
Search PDB for entries with ligand similarity: