Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50094075
Substrate
n/a
Meas. Tech.
ChEMBL_214878 (CHEMBL820244)
IC50
150±n/a nM
Citation
 Kondo, K; Ogawa, H; Shinohara, T; Kurimura, M; Tanada, Y; Kan, K; Yamashita, H; Nakamura, S; Hirano, T; Yamamura, Y; Mori, T; Tominaga, M; Itai, A Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template. J Med Chem 43:4388-97 (2000) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40761.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
371
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
  
Inhibitor
Name:
BDBM50094075
Synonyms:
(2-Chloro-4-pyrrolidin-1-yl-phenyl)-(2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-methanone | CHEMBL340893
Type:
Small organic molecule
Emp. Form.:
C21H23ClN2O
Mol. Mass.:
354.873
SMILES:
Clc1cc(ccc1C(=O)N1CCCCc2ccccc12)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: